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If additional glycemic control is needed after at least 4 weeks on the 0.5 mg dosage, the dosage may be increased to 1 mg once weekly

J.LinH.LiS.Huang-HC.2001The Effect of Ethanol on the Phase Transition Temperature and the Phase Structure of Monounsaturated Phosphatidylcholines

This is enabled by specific a sequence of both the propeptide and the mature part of the enzyme, which may include the disulfide bond formation between C143 in the mature part of Lm PC-PLC and one of the cysteines from the propeptide