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Only high priced and lighter and smaller items could take the shorter and quicker paddle steamer route over the Isthmus of Panama, nearly everything else had to travel the approximate 17,000 miles (27,000 km) and over 200-day route all sailing ship route around Cape Horn or the Straits of Magellan

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This response may be part of an emergency response with the sudden onslaught of oxidants from the CS exposure or it may be the depletion of GSH during the CS exposure combined with the increase in oxidants from CS that acts as a trigger to initiate this response