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Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

In these situations, oral B12 supplements are often useless because the digestive system can't properly absorb the nutrient

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125 Accordingly, genes encoding MMR components such as mutS homolog 2 (MSH2) and mutL homolog 1 (MLH1) are frequently mutated or downregulated in the context-acquired CDDP resistance
