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Children with this syndrome have three times more chances of developing cleft lip and palate Siderius X-linked intellectual disability consisting of cleft lip and palate along with facial dysmorphism and mild intellectual disability syndrome is caused due to mutations in (PHF)finger protein gene [14].8 Stickler syndrome includes cleft lip and palate, joint pain and myopia [15, 16]

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This phosphorylates and inhibits GFPT1, thereby weakening YAP protein stability and the transcription of its downstream target gene FTH1, ultimately promoting ferritinophagy, lipid peroxidation, and enhanced ferroptosis susceptibility (50)