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Description
In DFU, notch pathway dysfunction can lead to inhibition of cell differentiation, proliferation disorders, and reduced angiogenesis, all of which interfere with diabetic wound healing

Unlike standard cytoprotective agents that exhibit only prophylactic effectiveness (shared limitation of activity) [41,42,43,44,45,46,47,48], BPC 157 represents a prototype of a more effective class of cytoprotective agents with both prophylactic and therapeutic ability [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40]

doi: 10.1016/j.cell.2015.12.034

Chitosan oligosaccharide: biological activities and potential therapeutic applications
