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Fibrates are derivatives of fabric acid whose mechanism of action relies on the activation of the nuclear receptor peroxisome proliferator-activated receptors alpha (PPAR), which leads to several changes in metabolism, including a reduction in the production of APOC3 (the already mentioned physiological inhibitor LPL) and an increase in the expression of LPL, both alterations leading to a significant rise in LPL activity and a reduction in TG level in bloodstream [9,175-177]

w: weeks, g: grams, d: days, l: milliliter, min: minutes

conducted a cross-sectional survey of 107 bodybuilders recruited from gyms in the Naples metropolitan area and found that 35.5% admitted to the illegal use of hormones, although specific substances were not identified (89)

However, when bone marrow transplants from apoC1-KO or wild-type mice to apoE-KO mice were conducted to assess the specific effect of macrophage-derived apoC1 on the development of atherosclerosis, no difference was found for plasma either lipid levels or atherosclerotic lesions [128]