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The safe effective dose was estimated, and an acute oral toxicity study was carried out as per the OECD guidelines using the fixed dose method (OECD, 2000), as described previously [8]
In HCC, GLS1 can be induced by hepatocyte growth factor activated mesenchymal-epithelial transition factor (MET) signaling or by polypyrimidine tract-binding protein 1, both of which promote chemoresistance [228, 229]
doi: 10.9790/264X-0605021326 92
KangJYKimSKimJKangN-GYangC-SMinS-Jet alCell-penetrating peptide-conjugated lipid/polymer hybrid nanovesicles for endoplasmic reticulum-targeting intracellular delivery
