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This is known as thymic involution

Common effects: Injection-site reactions (mild redness, slight discomfort) most common Transient headaches (resolved without intervention) Mild fatigue in some subjects (usually early in treatment) No serious adverse events reported Laboratory changes: No significant changes in blood glucose or insulin levels No effects on liver enzymes or kidney function No changes in IGF-1 levels (confirming the absence of a GH rise) No clinically significant changes in other laboratory parameters Phase 2 trials (overweight/obese subjects): Efficacy trials in overweight and obese populations confirmed the favorable safety profile

Neutrophils were stained on fixed sections with monoclonal anti-Ly6G, whereas frozen samples were embedded in optimal cutting temperature compound, and sections were stained with monoclonal anti-CD301b or anti-TGM2 (See Table 2 for the antibodies used in this study)