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However, the authors of these meta-analyses listed some limitations that open the way for carrying out more RCTs to answer questions: a small number of available trials and high heterogeneity between included studies 107

The FDA warns that both CJC-1295 and ipamorelin are risky for immunogenicity, potentially causing life-threatening outcomes such as anaphylaxis.25 26 Cardiovascular concerns: Specifically concerning CJC-1295, the FDA warns of the risk of increased heart rate and systemic vasodilatory reaction, including flushing, warmth, and transient hypotension.25 27 Cancer: With their ability to increase the rate of cellular replication, growth hormone secretagogues in general are unsafe for cancer survivors and people with an active cancer diagnosis.28 Secretagogue use may elevate their risk for recurrence or worsen their prognosis

To get more complete and reliable data, Novo Nordisk has since launched a new phase 3 program called RENEW

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