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Efficacy and safety of nipocalimab in patients with moderate to severe active rheumatoid arthritis (RA): the multicenter, randomized, double-blinded, placebo controlled phase 2a IRIS-RA study

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The precise molecular identity of these binding sites remains under active investigation, but their characterisation has strengthened the mechanistic basis for Semax's CNS activity and supported its classification as a compound with defined receptor-level pharmacology rather than merely non-specific neuromodulatory effects

A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted