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It serves as the rate-limiting enzyme for the de novo synthesis of GSH, which is promoted by glutamate cysteine ligase (GCL) and glutathione synthetase (GSS)

Arginine metabolic regulators such as spermidine have been shown to suppress M1 macrophage-associated cytokines while inducing M2 macrophage-related markers, significantly alleviating EAE symptoms, whereas Arg1 inhibitors can reverse these effects ( In other autoimmune diseases, amino acid metabolic reprogramming likewise participates in the formation of the inflammatory microenvironment by regulating macrophage polarization

Use the Louvain algorithm to identify cell clusters with a resolution of 0.5