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198 In the context of obesity, increased hepatic expression of the unconventional prefoldin RPB5 interactor (URI) has been shown to couple nutrient surplus with inflammation, leading to nonalcoholic steatohepatitis (NASH) and consequent HCC

Serious side effects (rare but important) Pancreatitis is the most significant risk

Based on the results obtained, curcumin demonstrated promising cytotoxic activity against metastatic oral squamous cell carcinoma cells in both two-dimensional and three-dimensional models, with the effect being concentration- and time-dependent, and with tumor spheroids exhibiting greater resistance to treatment

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