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Description
Epigenetic alterations induced by hyperglycemia, including increased methylation at H4K20, acetylation at H3K9, and LSD1-mediated demethylation at H3K4, affect the promoter and enhancer regions of SOD2, resulting in its downregulation
Conchillo M, de Knegt RJ, Payeras M, Quiroga J, Sangro B, Herrero JI, Castilla-Cortazar I, Frystyk J, Flyvbjerg A, Yoshizawa C: Insulin-like growth factor I (IGF-I) replacement therapy increases albumin concentration in liver cirrhosis: results of a pilot randomized controlled clinical trial
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