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After positive results from the Veterans Affairs HDL-C Intervention trial (VA-HIT) trial, showing a 22% reduction in ASCVD with gemfibrozil (1,200 mg/day) in the 1990s [8], major fibrate trials, including the Lower Extremity Arterial Disease Event Reduction (LEADER) [5], Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) [6], and Action to Control Cardiovascular Risk in Diabetes (ACCORD)-Lipid [7] in the 2000s, failed to demonstrate ASCVD prevention with fibrates

Abstract Melanonychia, or melanin-derived brown-to-black nail pigmentation, is a diagnostic challenge for clinicians

Safety of drug therapies used for weight loss and treatment of obesity

[DOI] [PMC free article] [PubMed] [Google Scholar] 216.Nijmeijer R., Lagrand W.K., Lubbers Y.T.P., Visser C.A., Meijer C.J.L.M., Niessen H.W.M., Hack C.E