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Effect of diet-induced obesity or type 1 or type 2 diabetes on corneal nerves and peripheral neuropathy in C57Bl/6J mice

doi: 10.1126/science.286.5449.2498

We assessed the relative expression of multiple components of the cytochrome P450 system (CYP450) including CYP3A4, CYP1A2, CYP3A5, and CYP3A7

These findings reveal RSS complex regulatory network in different immune contexts: promoting T cell activation in anti-infection immunity while exerting inflammation-suppressing and tissue-protecting effects in excessive immune states
