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Its anabolic and growth-promoting effects are largely indirect, primarily via stimulation of hepatic IGF-1 production, whilst its direct metabolic effects, particularly those related to lipid metabolism and adipose tissue regulation, are believed to be mediated by specific domains within the GH molecule itself

However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

Proton pump inhibitors are often used to treat heartburn and indigestion by reducing the amount of acid produced by the stomach