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Over-activation of NMDARs leads to calcium overload of postsynaptic neurons, inducing excitatory toxicity, neuronal apoptosis, and neurodegeneration

The translation of these findings requires cautious interpretation and further rigorous human studies to establish efficacy, safety, and optimal dosing
.,WeydertCJCullenJJMeasurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue.2010;5(1):5166