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B vitamins play an important role in many of the body's functions, including energy production, nerve function, cognitive function, immune system function, and the synthesis of hormones and red blood cells

In most neuronal populations, ABCD1 is barely expressed, with the exception of certain neurons in the hypothalamus, the basal nucleus of Meynert, periaqueductal gray matter and locus coeruleus [32]

this maintains the intracellular cysteine balance required for GSH synthesis, thereby decreasing basal GSH levels 17,18

5-FU weakened the activities of antioxidant defense enzymes due to excessive production of ROS and other free radical formation, as reported (4042)