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These elements interact synergistically, creating a selfperpetuating cycle where, for instance, a history of childhood adversity (stressor) may increase vulnerability to catastrophizing (psychological factor) following a new injury (prior pain event), thereby dramatically elevating the risk of transition to a chronic, nociplastic pain state

Peer review Peer review information Nature Reviews Immunology thanks Z.-J

The results indicated a significant improvement in H-Y grading within the experimental group compared to the control group (MD = 0.15, 95% CI [0.28, 0.01], p = 0.03), with no observed heterogeneity ( I 2 = 0%, p = 1.00) (Figure 15)

Discussion Targeted proteomics was used to evaluate potential markers of type 1 diabetes in youth from the first 100 ND individuals recruited to the INNODIA study