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Experiments in mice have shown that the activation of the noradrenergic system of the LC by FGF21 reduces the intoxication effects of ethanol

Herein, our study provided new insights into the function of NF1 in GBC and highlighted the importance of YAP1 stabilization in promoting GBC tumorigenesis

Acknowledgements The authors acknowledge the efforts of Prof Omnia ElRashidy one of the founders of the Pediatric Ketoclinic and Prof Ehab Khairy Emam the Head of the Pediatric Gastroenterology, Hepatology and Clinical Nutrition Unit, at the children`s Hospital, Faculty of Medicine, Ain shams University, for their support