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FDA approval: Ribociclib for the treatment of postmenopausal women with hormone receptor-positive, HER2-negative advanced or metastatic breast cancer

42 Additionally, ATP production from normal mitochondrial respiration negatively regulates mitochondrial NOX4-induced ROS production through direct interaction between ATP and the NOX4 Walker A binding motif, 43 which suggests mitochondrial NOX4 may play a dynamic role in metabolic function