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Proper supplementation involves more than simply taking the recommended dose

171 Trials in aging men with erectile dysfunction have found treatment with tribulus extract, at a dose of 250 mg three times daily for three months, can increase testosterone levels and improve erectile function without worsening lower urinary tract symptoms

doi:10.3390/ijerph14060591 76

Persistent synovitis can induce VEGF production, promoting neovascularization and increased vascular permeability (143), which may facilitate the influx of iron into the joint cavity and subchondral bone and recruit additional immune cells, thereby intensifying local oxidative stress and inflammatory cascades (144)