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It may not always present as obvious heartburn

[DOI] [PubMed] [Google Scholar] 105.Shaheen SO, Newson RB, Sherriff A, Henderson AJ, Heron JE, et al
People with psoriasis can benefit from keeping their immune systems as healthy as possible to improve their autoimmune response

The enzyme FADS1 then desaturates these species to form arachidonic acid (AA) and eicosapentaenoic acid (EPA), which can then be converted into C22-PUFAs (adrenic acid (AdA) and docosapentaenoic acid (DPAn-3)) by ELOVL2