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Due to a limited understanding of Johnes disease pathogenesis, immunology, and correlates of protection, it has been difficult to develop an effective vaccine to prevent the infection
[DOI] [PubMed] [Google Scholar] 39.Biewenga WJ, Rijnberk A, Mol JA
Persistent synovitis can induce VEGF production, promoting neovascularization and increased vascular permeability (143), which may facilitate the influx of iron into the joint cavity and subchondral bone and recruit additional immune cells, thereby intensifying local oxidative stress and inflammatory cascades (144)
