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Introduction The spread of antibiotic resistance in the hospital environment and in community settings particularly where biofilms are involved, has spurred development of new strategies to design innovative therapeutics to curtail the spread of resistance

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These substances can activate key pro-inflammatory signaling pathways such as nuclear factor kappa B (NF-B), thereby inducing the gene transcription and protein secretion of extracellular matrix (ECM) degrading enzymes like matrix metalloproteinase 13 (MMP13) and A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 (ADAMTS5) (Miao et al., 2022