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However, although these actions have been scientifically proven, considerable research is still required to confirm the safe usage of these mediators as herbal medicines in the substitute or adjunctive handling of depressive disorders [180, 217]

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Prior to eventual internalization by distant immune cells, the formation of MVs, which also contain important immune-cell receptors and inhibitory complement receptors, may contribute to an immune or tolerogenic microenvironment for MM cells in the bone marrow (BM) niche [25] [26]

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