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Cancer 20 , 471480 (2020)

Abbreviations BBB: Bloodbrain barrier BrdU: Bromodeoxyuridine CNS: Central Nervous System DG: Dentate gyrus GCL: Granular cell layer GDF11: Growth Differentiation Factor 11 IP: Intraperitoneal NSC: Neural stem cell OPC: Oligodendrocyte precursor cell rGDF11: Recombinant GDF11 SGZ: Subgranular zone SVZ: Subventricular zone TAM: Tamoxifen TGF-: Transforming growth factor-beta References McPherron AC, Lawler AM, Lee S-J

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Since B12 helps with energy levels, patients are more motivated to continue their diets and exercise, more than those who are not receiving B12 injections