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In mouse models of ASCVD (e.g., LDLR -/- ), a high-fat diet expands bone marrow progenitors and promotes myelopoiesis, accompanied by long-term epigenetic changes linked to NLRP3 inflammasome activation and increased IL-1 secretion

In addition to suppressing p-STAT3 expression, GHK-Cu may utilize additional pathways to inhibit inflammatory factors

The systematic oxidation of these polyunsaturated fatty acids is called lipid peroxidation

Adjunct synergies: Ex vivo/cell studies note synergy between GHK-Cu and hyaluronic acid on collagen IV (and I/VII) generation, suggesting formulation-level complementarity (PubMed)