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22 Long-term use of glucocorticoids induces and exacerbates infections, cause hyperglycaemia, osteoporosis and even mental disorders

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This is because: It does not have its own blood supply It gets nutrients slowly from nearby fluids Healing cells dont reach it easily So when cartilage gets damaged, it heals very slowly and sometimes not at all

Cancer Res 76 , 45464558 (2016)
