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Several assays have been used to determine the binding potency of insulin analogs such as (a) the in vivo mouse convulsion assay, (b) in vitro receptor binding studies of analogs in competition with radio-iodinated insulin, and (c) by the ability of insulin analogs to enhance 14 C-glucose oxidation, or conversion of 3 H-glucose into lipids in adipocytes

Metabolically, it reduced hyperinsulinemia and improved insulin sensitivity (HOMA-IR), accompanied by enhanced ovarian antioxidant defenses

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Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research