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In addition, the 2A - and 2B - receptors have been shown to localize in the plasma membrane, while the 2C receptors reside in intracellular compartments and translocate to the plasma membrane under certain physiologic or pathophysiologic stimuli (DeGraff et al., 1999

Cell 78 , 1017 (1994)

A phase 1 trial (synonymous with dose-escalation or human pharmacology studies) is the first instance in which a new investigational agent is studied in humans

We also discuss the current understanding of dopaminergic regulation of immune signaling in the CNS and peripheral tissues, highlighting the role of dopaminergic immunomodulation in diseases such as Parkinsons disease, several neuropsychiatric conditions, neurologic human immunodeficiency virus, inflammatory bowel disease, rheumatoid arthritis, and others