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FIGURE 1 Initially, the degradation of extracellular GSH by membrane-bound -glutamyltransferases (GTs) was considered the major pathway for GSH breakdown ( ChaC-like family proteins are remarkably conserved, being found across all phyla from bacteria to humans, where they catalyze intracellular GSH degradation and yield 5-oxoproline and cysteinylglycine (Figure 2)

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