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Certain people notice increased agitation or hyperactivity after supplementation

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The microbial metabolite trimethylamine N-oxide links vascular dysfunctions and the autoimmune disease rheumatoid arthritis

However, in clinical trials targeting severe cognitive impairment, chronic fatigue syndrome, or neuropathy, therapeutic doses usually range from 1,500 mg to 3,000 mg (1.5g 3g) daily
