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These factors can often cause wrinkle formation

In chronic liver disease, after phagocytosis of hepatocyte debris, hepatic macrophages secrete Wnt-3a, as an activator of Wnt/-catenin signaling in hepatic progenitor cells (HPCs) to promote their differentiation into hepatocytes 22 ( Figure 2 )

doi: 10.1016/s1097-2765(00)80446-3
