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Chronic Fatigue Management Low levels of glutathione are often associated with chronic fatigue, as oxidative stress can impair cellular energy production

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10.1016/j.jep.2014.12.044 126 MaF.-W.DengQ.-F.ZhouX.GongX.-J.ZhaoY.ChenH.-G.et al (2016)

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However, it's important to contextualize this assessment within the limitations of the available evidence: most safety data comes from relatively small studies, often of short-to-moderate duration, conducted primarily in the Soviet Union, Russia, and Eastern Europe where methodological standards and reporting practices have sometimes differed from Western pharmaceutical trial requirements

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N-acetylcysteine (NAC) replenishes intracellular GSH levels and enhances the antioxidant defenses of neural cells

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