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As shown in Table 5, 74 ligands presented non-representative binding modes and were considered automatically non-binders of GR

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Other factors include increased serum matrix metalloproteinases (Li et al., 2013), decreased collagen type ratio, dysregulated expression of skin neuropeptides (Nowak et al., 2021), lack of thrombin activated fibrinolytic inhibitor (Nass et al., 2010), decreased number of epidermal nerves ( Angiopoietin-like factor 4 (ANGPTL4) is a stromal cell protein that plays an important role in lipid and glucose metabolism and promotes keratinocyte migration, proliferation and angiogenesis