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Bruker Corporation, Billerica, MA, USA) with chloroform as a solvent

Besides chemoresistance, the ability to survive in hypoxia is also significant for tumor cells

A hallmark of HCC progression is the loss of tyrosine catabolism, which results in elevated serum tyrosine levels and is frequently associated with the inhibition of the enzyme 4-hydroxyphenylpyruvate dioxygenase (4-HPD) [11]

Subsequently, STRING analysis was performed on a group of genes that showed variation as a result of quantitative measurement of gene expression by RT-qPCR
