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Description
Growth factors such as (e.g., VEGF, platelet-derived growth factor [PDGF] bind to a receptor tyrosine kinase (RTK) on the cell membrane, causing autophosphorylation of the receptor, thus creating docking sites for intracellular signaling proteins
Ginjom, M
10.1016/j.cell.2019.01.015 Cell 222 SultanS.GebaraE
It is important to monitor renal and hepatic function during prolonged treatment
