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NADPH is the major regulator of cellular redox potential and is crucial for the action of different antioxidant systems, including the maintenance of reduced glutathione pools 29,31,53 (Fig

Phosphorylation of Tyr 816 leads to PLC-1 (phospholipase C) activation, which through DAG (diacylglycerol) and IP 3 (inositol trisphosphate) results in activation of Ca 2+ and protein kinase C-regulated pathways that facilitate synaptic plasticity 1

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