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The allosteric plasticity of this simple molecular scaffold has obvious implications for evolvability of new biological outcomes, which in one case, the Zn II sensor Sa CzrA, appears to arise from a redistribution of internal dynamics important for DNA operator binding

The lower absolute weight loss compared to STEP 1 reflects the metabolic challenges specific to type 2 diabetes, but the improvement remained highly significant

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It is usually given in doses of 0.2 to 0.3 mg per day