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In people with reduced ALDH2 levels (and thus more acetaldehyde), alcohol is more likely to induce asthma.[ref] One study explains: Impaired ALDH2 activity leads to high peak levels of acetaldehyde and to histamine release. Studies show that inhaling acetaldehyde induces histamine-mediated airway constriction, such as is seen in asthma.[ref] Hangovers and histamine A recent animal study sheds light on the age-old question of what causes hangover symptoms

[PubMed] [Google Scholar] Tew KD, Monks A, Barone L, Rosser D, Akerman G, Montali JA, Wheatley JB and Schmidt DE Jr

Elevated levels of 4-HNE covalently modify scaffold proteins such as GM130 and GRASP65, resulting in Golgi stack disassembly and fragmentation

salts), since their definition relies on connected ring systems 44