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In the SURMOUNT-1 trial, tirzepatide at the highest dose (15 mg) produced average weight loss of 22.5% versus approximately 15% for semaglutide in comparable trials

How This Works IGF-1 DES is a naturally-shortened variant of IGF-1: removing the N-terminal Gly-Pro-Glu tripeptide (and specifically the glutamate at position 3) greatly weakens its affinity for the IGF-binding proteins that normally sequester circulating IGF-1 [1]

The FDA and the U.S
