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Increasing evidence points to neurodegeneration of the innermost retinal neurons, specifically the RGCs and their axons (forming the optic nerve), as a hallmark of optic neuropathies
This phenomenon was first identified in plants and invertebrates, which lack adaptive immunity, and is characterized by enhanced protection upon secondary challenge following a primary encounter
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[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Cunnane SC, Schneider JA, Tangney C, Tremblay-Mercier J, Fortier M, Bennett DA, Morris MC
