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The primary sources of oxidative stress in sperm include leukocyte activity, mitochondrial dysfunction, and environmental factors such as smoking and pollution
MOTS-c's AMPK activation aligns with the body's metabolic circadian rhythm, which peaks in the morning and early afternoon

[PMC free article: PMC3949112] [PubMed: 24477539] 183

Our cells have adapted to this potential toxicity by storing cysteine in the form of glutathione (GSH) [8] , which is far more stable to oxidation
