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In the treatment of children with an inborn error in the production of transcobalamin II, the binding protein that transports B12 to the cells, serum values are kept at levels of 10 000 pg/ml (about 7 400 pmol/L) without any side-effects

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While semaglutide does not require dose adjustment for mild to moderate renal impairment, experience in patients with severe renal impairment is limited
