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Because tissue repair in animal models typically requires both new blood vessel formation and coordinated cell movement, some researchers are interested in whether studying the two peptides in combination reveals synergistic effects that aren't apparent when each is studied in isolation

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In experiments with hFOB1.19 cells, MOTS-c treatment increased cell viability in a time-dependent manner and upregulated mRNA and protein expressions of TGF-, SMAD7, COL1A1, and COL1A2