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Alternatively, using endogenous OCTN1 transporters in natively expressed cells (e.g., HeLa cells), the primacy of EGT over other substrates, including TEA + , choline, acetylcholine, carnitine, acetylcarnitine, gabapentin, metformin, and particularly EGT metabolites with structural similarities (i.e., hercynine and S -methyl EGT), was confirmed, suggesting that OCTN1 has a high selectivity on EGT uptake and may contribute to trivial transport of other compounds without physiological relevancy

Based on our histopathological and biochemical findings, we propose a mechanistic model illustrating the neuroprotective effects of anakinra following cardiac arrest (Fig