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Mechanistically, AgNPs cross the bloodbrain barrier, provoke persistent oxidative stress, disrupt neuronal integrity, and impair synaptic signaling, collectively resulting in behavioral changes and long-term memory impairment (Wang et al., 2023)

When GSH was tested together with reduced PfGrx C88S or PfGrx C32S/C88S , the syringe of the stopped-flow spectrofluorometer also contained 0.4 U/mL glutathione reductase (GR) and 0.25 mM NADPH to ensure the removal of trace amounts of GSSG that might interfere with the redox measurements

"Glutathione Depletion and Concomitant Elevation of Susceptibility in Patients with Parkinson's Disease: State-of-the-Art MR Spectroscopy and Neuropsychological Study"

doi:10.4103/2249-4863.152255 Lewy A, Fox N