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At the same time, experts caution that stress alone does not prove a person has a separate leaky gut syndrome, since this is a complex, context-dependent process rather than a single diagnosis

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For example, mesio-temporal lobe epilepsy (MTLE) was significantly aggravated in mice with increased TrkB signals, but delayed in mutant mice with reduced TrkB signals

A 2026 International Journal of Molecular Sciences review confirmed plausible mechanisms: angiogenesis support, collagen synthesis, nitric oxide modulation all observed in animal models, not controlled human studies
