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The IGNITE network, funded by the NIH, is conducting a large multicenter randomized pragmatic trial to determine the effect of CYP2D6-guided opioid prescribing on chronic pain and post-operative pain control and opioid usage[163]
Clinically, this manifests as peripheral neuropathy, characterized by numbness, painful tingling, burning sensations in the extremities, and eventual loss of motor function
10.1016/j.niox.2020.01.002 [DOI] [PMC free article] [PubMed] [Google Scholar] Li B, Ming H, Qin S et al (2025) Redox regulation: mechanisms, biology and therapeutic targets in diseases
Rajamoorthi, A., LeDuc, C
